輝瑞宣佈於香港推出二價RSVpreF疫苗,用於針對60歲或以上長者因RSV病毒引起的下呼吸道疾病(LRTD),以及初生至六個月大嬰兒(於孕婦懷孕期間接種*)因RSV病毒引起的LRTD和嚴重LRTD。1輝瑞是目前唯一一間公司提供同時適用於長者及孕婦的RSV疫苗。
RSV 是一種傳染性病毒,是引致全球各地呼吸系統疾病的常見起因。3,4 該病毒會損害肺部和呼吸道,可能導致嬰兒(尤其是早產或6個月以下嬰兒)以及高風險長者群組出現嚴重併發症或死亡。4-6 於2019年,全球已錄得3,300萬宗與RSV相關的急性下呼吸道感染,其中101,400宗死亡個案涉及5歲或以下兒童。7 至於65歲或以上長者,在2015年,全球疾病負擔數字估計為33.6萬人入院、14,100人在住院期間死亡。8 在香港,RSV病毒是導致一歲以下幼童住院的頭號呼吸道病毒(佔超過一半案例),9 亦是住院長者死亡的常見原因。10
輝瑞香港及澳門區域總經理Krishnamoorthy Sundaresan表示:「這款二價RSVpreF疫苗在市場推出,再一次表明我們回應公共衛生需要的決心。透過此疫苗,我們可為免疫力較弱的群組 – 嬰兒和長者 – 提供針對RSV病毒的保護。」11
RSV疾病主要由RSV A及RSV B兩種病毒亞群引起,兩種病毒可共同流行或隨著每個週期交替主導。12 這款二價疫苗不含佐劑,並由兩種融合前F蛋白組成,以發揮針對RSV A和B病毒種類的理想效果,並已證明為安全有效。11
輝瑞香港及澳門醫學總監Eugenia Ng表示:「此疫苗亦配合香港衛生署的基層醫療健康藍圖,推動預防勝於治療的概念,以改善市民健康。現在除了長者之外,初生至六個月大嬰兒亦可得到保護,幫助他們抵抗嚴重RSV疾病,而RSV疾病在這些嬰兒中導致的疾病負擔最高。」在香港,每年每1萬名6個月或以下嬰兒中,就有233.4至311.2名因感染RSV病毒而需要入院接受治療。13
如欲了解更多最新二價RSV疫苗的相關資訊,請向所屬地區的醫護人員查詢。
*有關建議的懷孕週期接種時間表,請參閱所屬地區的處方信息。
References:
- Respiratory syncytial virus vaccine Prescribing Information. Pfizer Corporation Hong Kong Limited: Version MAR 2024.
- Respiratory syncytial virus vaccine (bivalent, recombinant) Package Leaflet. Pfizer Europe. Version: 08/2023.
- World Health Organization. Respiratory Syncytial Virus (RSV) disease. Available at: www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccine-standardization/respiratory-syncytial-virus-disease. Accessed May 2024.
- Centers for Disease Control and Prevention. RSV transmission. Available at: www.cdc.gov/rsv/about/transmission.html. Accessed May 2024.
- Centers for Disease Control and Prevention. Respiratory syncytial virus infection (RSV) – Older adults are at high risk for severe RSV infection fact sheet. Available at: www.cdc.gov/rsv/factsheet-older-adults.pdf. Accessed May 2024.
- Centers for Disease Control and Prevention. RSV in Infants and Young Children. Available at: www.cdc.gov/rsv/high-risk/infants-young-children.html. Accessed May 2024.
- Li Y, Wang X, Blau DM, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet 2022;399:2047-2064.
- Shi T, Denouel A, Tietjen AK, et al. Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: A systematic review and meta-analysis. J Infect Dis 2020;222:S577-S583.
- Chan PKS, Tam WWS, Lee TC, et al. Hospitalization incidence, mortality and seasonality of common respiratory viruses over a period of 15 years in a developed subtropical city. Medicine (Baltimore) 2015;94:e2024.
- Wang Y, Fekadu G, You JHS. Comparative Cost-Effectiveness Analysis of Respiratory Syncytial Virus Vaccines for Older Adults in Hong Kong. Vaccines 2023;11(10):1605. https://doi.org/10.3390/vaccines11101605
- Awosika AO, Patel P. Respiratory Syncytial Virus Prefusion F (RSVPreF3) Vaccine. [Updated 2024 Mar 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK594261/
- Ciarlitto, C., Vittucci, A.C., Antilici, L. et al. Respiratory Syncityal Virus A and B: three bronchiolitis seasons in a third level hospital in Italy. Ital J Pediatr 2019;45(115). https://doi.org/10.1186/s13052-019-0704-0
- Chiu SS, Chan KH, Chen H, et al. Virologically Confirmed Population-based Burden of Hospitalization Caused by Respiratory Syncytial Virus, Adenovirus, and Parainfluenza Viruses in Children in Hong Kong. Pediatr Infect Dis J 2010;29(12):1088-1092.
PP-A1G-HKG-0058 JUL 2024
消息來源: Pfizer
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